democapsid
Abstract
This work implements Caspar-Klug Theory to generate high-quality, vectorized capsid cartoons in the browser and is the first online tool that provides comprehensive style customization, geometry, and SVG export of icosahedra and nets with different lattice structures.
Run
- Run democapsid (v2.2.2): https://dnanto.github.io/democapsid/app.html.
build
npm run clean && \
npm run minify && \
npm run update && \
npm run zip && \
npm run tar
Paper
- Negrón, D. A. (2021). Vectorized Capsid Rendering in the Browser with Capsid.js (p. 2020.12.02.408252). https://doi.org/10.1101/2020.12.02.408252
- Negrón, D. A. (2021). Molecular Clock Analysis of Human Adenovirus [Ph.D., George Mason University]. In ProQuest Dissertations and Theses. http://www.proquest.com/docview/2572612100/abstract/9972F7D348C34013PQ/1
Poster
- ASM Microbe 2022 @ DC
- Spring 2021 GMU SSB Student Research Day 2021 @ GMU
- Fall 2020 SSB Student Research Day 2020 @ GMU
Demoscene
- 5th place at Demosplash 2021 for the combined demo/intro category (https://www.pouet.net/prod.php?which=90296)
Citation
- Please comment on or cite the preprint at bioRxiv, which is Chapter 2 of the dissertation.
- This work previously went by the name “capsid.js” and is now “democapsid”.
Cited by
- Hamann, M. V.; Beschorner, N.; Vu, X.-K.; Hauber, I.; Lange, U. C.; Traenkle, B.; Kaiser, P. D.; Foth, D.; Schneider, C.; Büning, H.; Rothbauer, U.; Hauber, J. Improved Targeting of Human CD4+ T Cells by Nanobody-Modified AAV2 Gene Therapy Vectors. PLOS ONE 2021, 16 (12), e0261269. https://doi.org/10.1371/journal.pone.0261269.
References
- Twarock, R., & Luque, A. (2019). Structural puzzles in virology solved with an overarching icosahedral design principle. Nature Communications, 10(1), 4414. https://doi.org/10.1038/s41467-019-12367-3
- Lehni, J., & Puckey, J. (2011). Paperjs/paper.js [JavaScript]. Paper.js. https://github.com/paperjs/paper.js
- Luque, A., & Reguera, D. (2010). The Structure of Elongated Viral Capsids. Biophysical Journal, 98(12), 2993–3003. https://doi.org/10.1016/j.bpj.2010.02.051
- Moody, M. F. (1965). The shape of the T-even bacteriophage head. Virology, 26(4), 567–576. https://doi.org/10.1016/0042-6822(65)90319-3
- Caspar, D. L., & Klug, A. (1962). Physical principles in the construction of regular viruses. Cold Spring Harbor Symposia on Quantitative Biology, 27, 1–24. https://doi.org/10.1101/sqb.1962.027.001.005