democapsid

Abstract

This work implements Caspar-Klug Theory to generate high-quality, vectorized capsid cartoons in the browser and is the first online tool that provides comprehensive style customization, geometry, and SVG export of icosahedra and nets with different lattice structures.

Run

• Run democapsid (v3.0.0): https://dnanto.github.io/democapsid/app.html.

Build

npm run deploy && npm install

Preprint

• Negrón, D. A., & Luque, A. (2026). Democapsid (arXiv:2606.28969; Version 1). arXiv. https://doi.org/10.48550/arXiv.2606.28969
• Negrón, D. A. (2021). Vectorized Capsid Rendering in the Browser with Capsid.js (p. 2020.12.02.408252). https://doi.org/10.1101/2020.12.02.408252
• Negrón, D. A. (2021). Molecular Clock Analysis of Human Adenovirus [Ph.D., George Mason University]. In ProQuest Dissertations and Theses. http://www.proquest.com/docview/2572612100/abstract/9972F7D348C34013PQ/1

Poster

• ASM Microbe 2022 @ DC
• Spring 2021 GMU SSB Student Research Day 2021 @ GMU
• Fall 2020 SSB Student Research Day 2020 @ GMU

Demoscene

• 5th place at Demosplash 2021 for the combined demo/intro category

Citation

• Please comment on or cite the preprint at arXiv.
• This work previously went by the name “capsid.js” and is now “democapsid”.

Cited by

• Hamann, M. V.; Beschorner, N.; Vu, X.-K.; Hauber, I.; Lange, U. C.; Traenkle, B.; Kaiser, P. D.; Foth, D.; Schneider, C.; Büning, H.; Rothbauer, U.; Hauber, J. Improved Targeting of Human CD4+ T Cells by Nanobody-Modified AAV2 Gene Therapy Vectors. PLOS ONE 2021, 16 (12), e0261269. https://doi.org/10.1371/journal.pone.0261269.

References

• Twarock, R., & Luque, A. (2019). Structural puzzles in virology solved with an overarching icosahedral design principle. Nature Communications, 10(1), 4414. https://doi.org/10.1038/s41467-019-12367-3
• Lehni, J., & Puckey, J. (2011). Paperjs/paper.js [JavaScript]. Paper.js. https://github.com/paperjs/paper.js
• Luque, A., & Reguera, D. (2010). The Structure of Elongated Viral Capsids. Biophysical Journal, 98(12), 2993–3003. https://doi.org/10.1016/j.bpj.2010.02.051
• Moody, M. F. (1965). The shape of the T-even bacteriophage head. Virology, 26(4), 567–576. https://doi.org/10.1016/0042-6822(65)90319-3
• Caspar, D. L., & Klug, A. (1962). Physical principles in the construction of regular viruses. Cold Spring Harbor Symposia on Quantitative Biology, 27, 1–24. https://doi.org/10.1101/sqb.1962.027.001.005

License

• MIT License

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